30. August 2018


Filed under: Video — Schlagwörter: — berndvo @ 08:06

19. November 2016

New gene-editing technology partially restores vision in blind animals

Filed under: Video — Schlagwörter: — berndvo @ 08:40

CRISPR-Genmanipulation erstmals an Menschen eingesetzt

Filed under: Presse — Schlagwörter: — berndvo @ 08:37

A team of scientists in China has become the first to treat a human patient with the groundbreaking CRISPR-Cas9 gene-editing technique. While the results of the trial are uncertain, it’s a historic milestone that should serve as a serious wakeup call to the rest of the world.

A research team led by oncologist Lu You at Sichuan University delivered modified immune cells into a patient suffering from an aggressive form of lung cancer. The scientists used CRISPR-Cas9 to make the cells more resilient in the presence of cancer, marking the first time that the powerful gene-editing tool was used to treat a human.

The study was limited to one patient in order to test the safety of CRISPR. Given the encouraging results, another 10 patients will be treated as part of an ongoing clinical trial being conducted at the West China Hospital in Chengdu.







1. August 2016

Chinese Scientists Will Perform First CRISPR Human Gene Editing Trial In August

Filed under: Presse — Schlagwörter: — berndvo @ 19:12

A team of scientists from the Sichuan University’s West China Hospital in Chengdu will begin the first CRISPR human trial for lung cancer patients in August of this year.  Patients who have failed to respond to treatments—who still haven’t gotten well even after undergoing chemotherapy, radiation therapy, and other treatments—were chosen to take part in the CRISPR trial.

Scientists plan to take T cells from patients and use the CRISPR-Cas9 technique to edit out the PD-1 gene. PD-1 regulates T cells’ immune response and prevents them from attacking healthy cells. The team will then multiply the modified samples in the lab before reintroducing them to the patients’ bloodstream, in the hopes that they’ll target parts of the patient’s body affected with cancer. A biotechnology company will validate the cells before they’re reintroduced into the patient to make sure only PD-1 was edited out.





23. April 2016

Liz Parrish of BioViva Sciences: Treating Biological Aging With Gene Therapy Mar-A-Lago 2015

Filed under: Video — Schlagwörter: — berndvo @ 07:22

First gene therapy successful against human aging

Filed under: Presse — Schlagwörter: — berndvo @ 07:19

American woman gets biologically younger after gene therapies

Elizabeth Parrish, CEO of Bioviva USA Inc. has become the first human being to be successfully rejuvenated by gene therapy, after her own company’s experimental therapies reversed 20 years of normal telomere shortening.

Telomere score is calculated according to telomere length of white blood cells (T-lymphocytes). This result is based on the average T-lymphocyte telomere length compared to the American population at the same age range. The higher the telomere score, the “younger” the cells.



Die Gentechnik und der Transhumanismus

Filed under: eigene Artikel — Schlagwörter: — berndvo @ 07:17

KÖLN. (hpd) Vom Standpunkt des Transhumanismus aus gesehen, ist der Alterungsprozess des menschlichen Körpers eine Erbkrankheit, die in Zukunft geheilt werden kann. Der Mensch ist das Ergebnis einer über Jahrmillionen abgelaufenen Evolution. Wesentlicher Bestandteil des Evolutionsprozesses ist die Selektion. Sie ist in der Regel ein ausgesprochen brutaler Prozess der mit extremem Leid verbunden ist. Die Naturwissenschaft ist nun mittlerweile so weit fortgeschritten, dass wir die zukünftige Weiterentwicklung des Menschen selbst in die Hand nehmen können. Sie wird uns in die Lage versetzen, das durch Krankheiten und Altern bedingte Leid zu reduzieren und die positiven Fähigkeiten des Menschen weiter zu optimieren. Während die Manipulation von Genen bis vor wenigen Jahren noch ein sehr aufwändiger Prozess war, hat sich dieser durch die Entwicklung der neuen CRISPR/Cas9-Technik nun drastisch vereinfacht.



4. Februar 2016

CRISPR Gene Editing Used to Repair Blindness-Causing Genetic Defect

Filed under: Uncategorized — Schlagwörter: — berndvo @ 15:01

A new gene-editing technology called CRISPR is now being used to repair a genetic mutation that causes retinitis pigmentosa (RP), which is an inherited condition that degrades the retina and leads to blindness in at least 1.5 million cases around the globe.

Scientists from the Columbia University Medical Center (CUMC) and University of Iowa worked together in this study, which was published in Scientific Reports.

This is the first time that researchers replaced a defective gene associated with a sensory disease in stem cells that were derived from a patient’s tissue. Our vision is to develop a personalized approach to treating eye disease,” says Stephen Tsang, MD, PhD, the László Z. Bitó Associate Professor of Ophthalmology and associate professor of Pathology & Cell Biology at CUMC, ophthalmologist at New York-Presbyterian/Columbia, and one of the study’s senior authors. He adds that this is just the beginning, but that the results are promising: “We still have some way to go, but we believe that the first therapeutic use of CRISPR will be to treat an eye disease. Here we have demonstrated that the initial steps are feasible.”





Erbgut-Forschung: Großbritannien erlaubt Genmanipulation von Embryonen

Filed under: Presse — Schlagwörter: — berndvo @ 14:59

Ein britisches Forscherteam darf künftig gezielt die Gene menschlicher Embryonen verändern. Die Wissenschaftler wollen mehr herausfinden über Unfruchtbarkeit und Frühgeburten. Was sie nicht dürfen: die veränderten Zellen einer Frau einpflanzen.





17. Dezember 2015

The First Ever In-Human Gene Editing Will Try and Combat Hemophilia

Filed under: Presse — Schlagwörter: — berndvo @ 12:05
Gene Editing and the Treatment of Hemophilia B

The discovery of the CRISPR/Cas9 system forever changed our world, allowing scientists to quickly and efficiently edit DNA. Of course, we could edit DNA before; however, the methods were not terribly precise. And what is, perhaps, most notable about the CRISPR system is that it allows scientists to make their edits at a reasonable price. And in a world where scientific breakthroughs are largely determined by whether or not one is able to get funding for their research, the significance of affordable techniques simply cannot be overstated.

So how does it work? In short, Cas9 is one of the enzymes produced by the CRISPR system. It binds to DNA in a highly sequence-specific manner and cuts it, allowing for accurate DNA manipulation.

With this technique, gene editing has truly taken off. It is highly more efficient than the previous mainstream methods that make use of TAL Effector Nucleases (TALENS) and Zinc Finger Nucleases (ZFNs), and the new method paves way for more researches and, possibly, using the use of gene editing to treat human illnesses and ailments.

In fact, this is precisely what researchers from Richmond, California’s Sangamo BioSciences are trying to do.




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