24. August 2019

Ewiges Leben

Filed under: Video — Schlagwörter: — berndvo @ 10:53

25. März 2017

It’s Happening: Scientists Can Now Reverse DNA Ageing in Mice

Filed under: Presse — Schlagwörter: — berndvo @ 16:37

Researchers have identified a cellular mechanism that allows them to reverse ageing in mouse DNA and protect it from future damage. They’ve shown that by giving a particular compound to older mice, they can activate the DNA repair process and not only protect against future damage, but repair the existing effects of ageing. And they’re ready to start testing in humans within six months.

„The cells of the old mice were indistinguishable from the young mice, after just one week of treatment,“ said lead researcher David Sinclair from the University of New South Wales (UNSW) in Australia and the Harvard Medical School in Boston. „This is the closest we are to a safe and effective anti-ageing drug that’s perhaps only three to five years away from being on the market if the trials go well.“

Sinclair and his team made headlines back in 2013 when they found that the cells of younger mice contained more of a compound called nicotinaminde adenine dinucleotide, or NAD+, than their older counterparts. Not only that, but when they gave the older mice more NAD+, they started to look younger, too. It was a big deal at the time, but one of the tricky things about medicine is that in order to show that something could work as a potential treatment, you need to first understand how it’s acting in the body. And although the researchers knew NAD+ was having an impressive effect, they couldn’t say for sure how it was doing it.



24. Oktober 2016

First phase 1 human aging reversal trials (GDF, Myostatin) in a year or two and George Church discusses how to affordably rejuvenate the whole body

Filed under: Presse — Schlagwörter: — berndvo @ 15:45

The new goal is to reverse aging, not only in animals, but in humans. And age reversal is essential, as significant age-related disruption has already occurred in most people due to changes in our gene expression profiles.

Gene expression patterns change with age. This influences the rate at which an individual ages, and also determines what senile disorders they are likely to contract. But innovative gene-editing methods based on a unique technology called CRISPR (clustered regularly interspaced short palindromic repeats) are now being successfully harnessed for use as an age-reversal therapy for humans.

In response to these breakthroughs, Life Extension® magazine sent biogerontologist Dr. Gregory M. Fahy to Harvard University to interview Dr. George Church, who is a leading developer of cutting-edge CRISPR techniques. Here, Dr. Church explains remarkable opportunities for transforming human aging that may begin to unfold sooner than most have imagined.

The first phase I aging reversal human trials could be in a year or two
Fahy: Using your most favorable pathway for intervention, how long will it take before a human trial might be possible?

Church: I think it can happen very quickly. It may take years to get full approval, but it could take as little as a year to get approval for phase one trials. Trials of GDF11, myostatin, and others are already underway in animals, as are a large number of CRISPR trials. I think we’ll be seeing the first human trials in a year or two.




14. Juni 2015

US-Forscher sicher: Können Lebenserwartung verzehnfachen

Filed under: Presse — Schlagwörter: — berndvo @ 06:48

Dem menschlichen Leben sind keine festen Grenzen gesetzt – diese Theorie vertreten nun zumindest US-Forscher in einer neuen Studie. Demnach ließe sich die Lebenserwartung verfünf- oder gar verzehnfachen. Unterstützung für ihre These finden die Wissenschaftler in der Natur.

„Wenn Evolution unsere Lebensspanne bestimmt, dann können wir sie verändern, indem wir in den Mechanismus eingreifen“: Diese Worte stammen von Yaneer Bar-Yam, dem Leiter einer nun veröffentlichten Studie, aus der die „Welt kompakt“ zitiert. Darin geht es um die Lebensdauer der Menschen, die nach Meinung der Forscher noch lange nicht ihr Maximum erreicht habe.

„Es ist durchaus vorstellbar, dass sich die Lebenserwartung von Menschen verfünffachen, sogar verzehnfachen lässt“, erklärt Bar-Yam. Basis für die Aussagen des Forschers sei ein neuartiges mathematisches Modell, das zu jenen Ergebnissen geführt habe. Dabei seien die Alterungs- und Sterbeprozesse von Menschen und Tieren untersucht worden.


28. Januar 2015

Telomere extension turns back aging clock in cultured human cells, study finds

Filed under: Presse — Schlagwörter: — berndvo @ 10:33

Researchers delivered a modified RNA that encodes a telomere-extending protein to cultured human cells. Cell proliferation capacity was dramatically increased, yielding large numbers of cells for study.

A new procedure can quickly and efficiently increase the length of human telomeres, the protective caps on the ends of chromosomes that are linked to aging and disease, according to scientists at the Stanford University School of Medicine.

Treated cells behave as if they are much younger than untreated cells, multiplying with abandon in the laboratory dish rather than stagnating or dying.

The procedure, which involves the use of a modified type of RNA, will improve the ability of researchers to generate large numbers of cells for study or drug development, the scientists say. Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells. The research may point to new ways to treat diseases caused by shortened telomeres.




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